Efeito de intervenção intensiva no estilo de vida por 12 meses sobre a esteatose hepática em adultos com diabetes tipo 2

Efeito de intervenção intensiva no estilo de vida por 12 meses sobre a esteatose hepática em adultos com diabetes tipo 2     São Paulo, 18 de Outubro de 2010 Perda de peso através de mudanças do estilo de vida é recomendada na doença hepática gordurosa não alcoólica (DHGNA). Todavia, sua eficácia em pacientes com diabetes tipo 2 não é comprovada.   Pesquisadores publicaram, recentemente, no Diabetes Care, resultados do estudo Look AHEAD (Ação para Saúde em Diabetes), um ensaio clínico de 16 centros que incluiu 5145 adultos sobrepeso ou obesos com diabetes tipo 2, randomicamente alocados para uma intervenção intensiva no estilo de vida (IIEV) para induzir perda ponderal mínima de 7% ou ao grupo controle, que recebeu apoio e educação para o diabetes (AED). No Estudo Auxiliar de Gordura Hepática, 96 participantes completaram a espectroscopia por ressonância magnética com próton para quantificar a esteatose hepática e testes para excluir outras causas de doença hepática em momento basal e após 12 meses. Esteatose > 5,5% foi definida como DHGNA.   No total, 49% dos participantes era feminina e 68% era caucasiana. A idade média foi igual a 61 anos, o IMC médio foi igual a 35 kg/m², a média da esteatose foi igual a 8,0% e os valores médios de AST (aspartato-aminotransferase) e de ALT (alanino-aminotransferase) foram iguais, respectivamente, a 20,5 e 24,2 U/L. Após 12 meses, os participantes alocado no grupo IIEV (n = 46) perderam mais peso (–8,5 % vs –0,05%; P <  0,01) que os participantes alocados para AED e apresentaram maior redução da esteatose (–50,8 vs –22,8%; P = 0,04) e da HbA1c (–0,7 vs –0,2%; P = 0,04). Não houve alterações significativas dos níveis de AST e de ALT. Após 12 meses, 26% dos participantes do grupo AED e 3% (1 de 31) dos participantes do grupo IIEV sem DHGNA em momento basal desenvolveram DHGNA (P < 0,05).   Os pesquisadores concluíram que a intervenção intensiva no estilo de vida de 12 meses em pacientes com diabetes tipo 2 reduz esteatose e a incidência de doença hepática gordurosa não alcoólica. Uma resenha de Effect of a 12-month intensive lifestyle intervention on hepatic steatosis in adults with type 2 diabetes - Diabetes Care; 2010;33:215 – 2163

 

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Strategies to Reduce Sodium Intake; Strengthening the National Institute of Justice; Front-of Package Nutrition Rating Systems and Symbols

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Dear Subscriber, Join us this weekend at the USA Science & Engineering Festival Expo on the National Mall. Our theme, "Because Dreams Need Doing," sets the stage for a variety of fascinating things for you to see and do in Tent #102. Can't be there in person? You can still participate. Follow the conversation on Twitter, using #NAX #scifest. Strategies to Reduce Sodium Intake in the United States Reducing the intake of sodium is an important public health goal for Americans. Since the 1970s, an array of public health interventions and national dietary guidelines has sought to reduce sodium intake. However, the U.S. population still consumes more... Examination of Front-of-Package Nutrition Rating Systems and Symbols: Phase I Report Prepublication Available The federal government requires that most packaged foods carry a standardized label--the Nutrition Facts panel--that provides nutrition information intended to help consumers make healthful choices. In recent years, manufacturers have begun to include... Strengthening the National Institute of Justice The National Institute of Justice (NIJ) is the nation's primary resource for advancing scientific research, development, and evaluation on crime and crime control and the administration of justice in the United States. Headed by a presidentially appointed... Understanding the Demand for Illegal Drugs Despite efforts to reduce drug consumption in the United States over the past 35 years, drugs are just as cheap and available as they have ever been. Cocaine, heroin, and methamphetamines continue to cause great harm in the country, particularly in minority... Improving Water Quality in the Mississippi River Basin and Northern Gulf of Mexico: Strategies and Priorities Prepublication Available Most water resources managers, scientists, and other experts would agree that nonpoint source pollution is a more pressing and challenging national water quality problem today than point source pollution. Nonpoint sources of pollutants include parking lots... Sequence-Based Classification of Select Agents: A Brighter Line Select Agents are defined in regulations through a list of names of particularly dangerous known bacteria, viruses, toxins, and fungi. However, natural variation and intentional genetic modification blur the boundaries of any discrete Select Agent list based... Management and Effects of Coalbed Methane Produced Water in the United States In some coalbeds, naturally occurring water pressure holds methane--the main component of natural gas--fixed to coal surfaces and within the coal. In a coalbed methane (CBM) well, pumping water from the coalbeds lowers this pressure, facilitating the release... Building Community Disaster Resilience through Private-Public Collaboration Prepublication Available Natural disasters--including hurricanes, earthquakes, volcanic eruptions, and floods--caused over 220,000 deaths worldwide in the first half of 2010 and wreaked havoc on homes, buildings, and the environment. To withstand and recover from natural and... Public Health Effectiveness of the FDA 510(k) Clearance Process: Balancing Patient Safety and Innovation: Workshop Report The Food and Drug Administration (FDA) is responsible for assuring that medical devices are safe and effective before they go on the market. As part of its assessment of FDA's premarket clearance process for medical devices, the IOM held a workshop June 14-15... Reducing Sodium Intake in the United States Download Podcast Unsubscribe To unsubscribe from this list please go here or reply to this message with "unsubscribe" in the subject line. To manage your subscriptions and account preferences go here. Copyright © 2010. National Academies Press. 500 Fifth St. N.W., Washington, D.C. 20001. Privacy Statement

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From: Murillo Santucci Cesar de Assunção <murilloa@uol.com.br>
Sent: Tue, November 2, 2010 7:19:56 PM
Subject:  11 great papers [Archivos adjuntos 11]

Ellinor et al. Arrhythmogenic right ventricular cardiomyopathy. Heart Failure Clinics (2010) vol. 6 (2) pp. 161-77

MacRae. The genetics of congestive heart failure. Heart Failure Clinics (2010) vol. 6 (2) pp. 223-30

Shin and Semigran. Heart failure and pulmonary hypertension. Heart Failure Clinics (2010) vol. 6 (2) pp. 215-22

Deo and MacRae. Clinical screening and genetic testing. Heart Failure Clinics (2010) vol. 6 (2) pp. 231-8

Lubitz et al. Genetics of atrial fibrillation. Heart Failure Clinics (2010) vol. 6 (2) pp. 239-47

Beinart et al. The genetics of conduction disease. Heart Failure Clinics (2010) vol. 6 (2) pp. 201-14

Sen-Chowdhry et al. Genetics of restrictive cardiomyopathy. Heart Failure Clinics (2010) vol. 6 (2) pp. 179-86

Ho. Hypertrophic cardiomyopathy. Heart Failure Clinics (2010) vol. 6 (2) pp. 141-59

Boussy et al. Genetic basis of ventricular arrhythmias. Heart Failure Clinics (2010) vol. 6 (2) pp. 249-66

Fatkin et al. Genetics of dilated cardiomyopathy. Heart Failure Clinics (2010) vol. 6 (2) pp. 129-40

Lubitz et al. Atrial fibrillation in congestive heart failure. Heart Failure Clinics (2010) vol. 6 (2) pp. 187-200

 

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